CONDITIONS TREATeD / DIABETES
Regenerate. Repair. Restore.
Stem Cells Therapy for Diabetes
WHAT IS STEM CELL THERAPY?
HOW STEM CELL THERAPY WILL HELP?
WHAT SETS US APART?
WHY STEM CELLS TRANSPLANT INSTITUTE?

About Diabetes
According to the World Health Organization, diabetes affects more than 422 million people worldwide and it is one of the leading causes of death. At The Stem Cells Transplant Institute in Costa Rica, we recommend mesenchymal stem cells (hUCMSCs) for the treatment of diabetes.
Stem cells can reproduce, but they can also differentiate or, become another cell type by dividing asymmetrically, forming another type of cell such as skin, cartilage, muscle, liver, brain, and heart tissue.
It is possible to isolate, grow, and differentiate stem cells from umbilical cord blood or tissue into different cells types.
In 2021, around 537 million adults worldwide, between 20 and 79 years old live with diabetes. As of the same year, diabetes had caused 6.7 million deaths (a high increase compared to the 1.6 million deaths in 2016).
Diabetes mellitus is a group of diseases that causes a person to have high levels of sugar (glucose) in the blood or hyperglycemia. When the levels of blood glucose rise, beta cells in the pancreas release insulin which tells the cells throughout the body to take the glucose from the blood.
In patients with type 1 diabetes, the immune system attacks and destroys the beta cells making it impossible for the pancreas to release insulin. This results in high levels of sugar in the blood all of the time which leads to long-term damage.
In patients with type 2 diabetes, the body’s cells do not utilize enough of the glucose in the blood because the are either unresponsive to insulin, the beta cells produce too much or too little insulin, or a combination.
Researchers are evaluating the use of stem cells to treat both type 1 and type 2 diabetes.
It is projected that by 2030, the number of people with diabetes will increase to 643 million, and 783 million by 2045.
Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation.
Diabetes mellitus, also known as hyperglycemia, is a group of diseases in which a person has high levels of blood sugar (glucose). When the blood glucose level rises, beta cells in the pancreas release insulin, instructing cells throughout the body to take glucose from the blood.
In type 1 diabetes, the immune system attacks and destroys the beta cells, making it impossible for the pancreas to secrete insulin. This results in constant high levels of sugar in the blood, which leads to long-term damage.
In type 2 diabetes, the body’s cells do not use enough of the glucose in the blood because they are either unresponsive to insulin, or the beta cells produce too much or too little insulin, or a combination.
Please fill this form
Scientific References:
- Fu et al. Stem cell transplantation therapy in Parkinson’s disease. SpringerPlus (2015) 4:597
- Joyce et al. Mesenchymal stem cell for the treatment of neurodegenerative disease. Regen Med. 2010, November, 5(6)933-946. Doi:10.2217/rme.10.72
- Helena Vilaça-Faria, António J. Salgado and Fábio G.
- Teixeira Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson’s disease. Cells2019, 8(2), 118; doi:3390/cells8020118
Teixeira, F.G.; Carvalho, M.M.; Neves-Carvalho, A.; Panchalingam, K.M.; Behie, L.A.; Pinto, L.; Sousa, N.; Salgado, A.J. Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation. Stem Cell Rev.2015, 11, 288–297. [Google Scholar] [CrossRef] [PubMed] - Gao, F.; Chiu, S.M.; Motan, D.A.; Zhang, Z.; Chen, L.; Ji, H.L.; Tse, H.F.; Fu, Q.L.; Lian, Q. Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis.2016, 7, e2062. [Google Scholar] [CrossRef] [PubMed]
- Joyce, N.; Annett, G.; Wirthlin, L.; Olson, S.; Bauer, G.; Nolta, J.A. Mesenchymal stem cells for the treatment of neurodegenerative disease. Med.2010, 5, 933–946. [Google Scholar] [CrossRef] [PubMed]
- Fraga, J.S.; Silva, N.A.; Lourenco, A.S.; Goncalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; Manadas, B.; Sousa, N.; Salgado, A.J. Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations. Biochimie2013, 95, 2297–2303. [Google Scholar] [CrossRef] [PubMed]
- Ribeiro, C.A.; Fraga, J.S.; Graos, M.; Neves, N.M.; Reis, R.L.; Gimble, J.M.; Sousa, N.; Salgado, A.J. The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations. Stem Cell Res. Ther.2012, 3, 18. [Google Scholar] [CrossRef]
- Ribeiro, C.A.; Salgado, A.J.; Fraga, J.S.; Silva, N.A.; Reis, R.L.; Sousa, N. The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures). Tissue Eng. Regen. Med.2011, 5, 668–672. [Google Scholar] [CrossRef]
- Salgado, A.J.; Fraga, J.S.; Mesquita, A.R.; Neves, N.M.; Reis, R.L.; Sousa, N. Role of human umbilical cord mesenchymal progenitors conditioned media in neuronal/glial cell densities, viability, and proliferation. Stem Cells Dev.2010, 19, 1067–1074. [Google Scholar] [CrossRef]
- Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D. Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF. Rep.2017, 7, 4153. [Google Scholar] [CrossRef]
- Serra, S.C.; Costa, J.C.; Assuncao-Silva, R.C.; Teixeira, F.G.; Silva, N.A.; Anjo, S.I.; Manadas, B.; Gimble, J.M.; Behie, L.A.; Salgado, A.J. Influence of passage number on the impact of the secretome of adipose tissue stem cells on neural survival, neurodifferentiation and axonal growth. Biochimie2018, 155, 119–128. [Google Scholar] [CrossRef]
- Assuncao-Silva, R.C.; Mendes-Pinheiro, B.; Patricio, P.; Behie, L.A.; Teixeira, F.G.; Pinto, L.; Salgado, A.J. Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth. Biochimie2018, 155, 83–91. [Google Scholar] [CrossRef] [PubMed]